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Abstract Hardy–Weinberg proportions (HWP) are often explored to evaluate the assumption of random mating. However, in autopolyploids, organisms with more than two sets of homologous chromosomes, HWP and random mating are different hypotheses that require different statistical testing approaches. Currently, the only available methods to test for random mating in autopolyploids (i) heavily rely on asymptotic approximations and (ii) assume genotypes are known, ignoring genotype uncertainty. Furthermore, these approaches are all frequentist, and so do not carry the benefits of Bayesian analysis, including ease of interpretability, incorporation of prior information, and consistency under the null. Here, we present Bayesian approaches to test for random mating, bringing the benefits of Bayesian analysis to this problem. Our Bayesian methods also (i) do not rely on asymptotic approximations, being appropriate for small sample sizes, and (ii) optionally account for genotype uncertainty via genotype likelihoods. We validate our methods in simulations and demonstrate on two real datasets how testing for random mating is more useful for detecting genotyping errors than testing for HWP (in a natural population) and testing for Mendelian segregation (in an experimental S1 population). Our methods are implemented in Version 2.0.2 of thehwepR package on the Comprehensive R Archive Networkhttps://cran.r‐project.org/package=hwep. 

A key challenge facing the use of machine learning (ML) in organizational selection settings (e.g., the processing of loan or job applications) is the potential bias against (racial and gender) minorities. To address this challenge, a rich literature of Fairness-Aware ML (FAML) algorithms has emerged, attempting to ameliorate biases while maintaining the predictive accuracy of ML algorithms. Almost all existing FAML algorithms define their optimization goals according to a selection task, meaning that ML outputs are assumed to be the final selection outcome. In practice, though, ML outputs are rarely used as-is. In personnel selection, for example, ML often serves a support role to human resource managers, allowing them to more easily exclude unqualified applicants. This effectively assigns to ML a screening rather than a selection task. It might be tempting to treat selection and screening as two variations of the same task that differ only quantitatively on the admission rate. This paper, however, reveals a qualitative difference between the two in terms of fairness. Specifically, we demonstrate through conceptual development and mathematical analysis that miscategorizing a screening task as a selection one could not only degrade final selection quality but also result in fairness problems such as selection biases within the minority group. After validating our findings with experimental studies on simulated and real-world data, we discuss several business and policy implications, highlighting the need for firms and policymakers to properly categorize the task assigned to ML in assessing and correcting algorithmic biases. 

Abstract Enhancing the resilience and reliability of power grids is crucial amid rising cyber threats and system complexities. To address these challenges, this paper proposes an energy‐efficient, consortium blockchain‐based global alarm system for power grid management. Using smart contracts and the proof of‐authority consensus algorithm, the alarm system triggers global alarms upon detecting local anomalies, ensuring a prompt response to partition the power grid and mitigate failures. The effectiveness is validated by simulating the Iberian power system with 15 providers from various regions. Key metrics, such as load shedding, damage reduction, energy consumption, latency, and transaction costs, are used to assess the performance. Through simulations, we show that the blockchain‐based system effectively limits the damage propagation and the load shedding during cascading failures by delaying the onset of instability and maintaining lower damage levels compared to non‐blockchain scenarios. Our investigations reveal that the proposed global alarm mechanism reduces the damage and load shedding by up to 29% and 87%, respectively, showcasing its potential for preventing widespread outages. 

Abstract Steroid hormones are often synthesized in multiple tissues, affect several different targets, and modulate numerous physiological endpoints. The mechanisms by which this modulation is achieved with temporal and spatial specificity remain unclear. 17β‐estradiol for example, is made in several peripheral tissues and in the brain, where it affects a diverse set of behaviors. How is estradiol delivered to the right target, at the right time, and at the right concentration? In the last two decades, we have learned that aromatase (estrogen‐synthase) can be induced in astrocytes following damage to the brain and is expressed at central synapses. Both mechanisms of estrogen provision confer spatial and temporal specificity on a lipophilic neurohormone with potential access to all cells and tissues. In this review, I trace the progress in our understanding of astrocytic and synaptic aromatization. I discuss the incidence, regulation, and functions of neuroestradiol provision by aromatization, first in astrocytes and then at synapses. Finally, I focus on a relatively novel hypothesis about the role of neuroestradiol in the orchestration of species‐specific behaviors. 

Abstract Rotational temperatures in the Mesosphere‐Lower Thermosphere region are estimated by utilizing the OH(6,2) Meinel band nightglow data obtained with an Ebert‐Fastie spectrometer (EFS) operated at Arecibo Observatory (AO), Puerto Rico (18.35°N, 66.75°W) during February‐April 2005. To validate the estimated rotational temperatures, a comparison with temperatures obtained from a co‐located Potassium Temperature Lidar (K‐Lidar) and overhead passes of the Sounding of the Atmosphere by Broadband Emission Radiometry (SABER) instrument onboard NASA's Thermosphere Ionosphere Mesosphere Energetics and Dynamics (TIMED) satellite is performed. Two types of weighting functions are applied to the K‐Lidar temperature profiles to compare them with EFS temperatures. The first type has a fixed peak altitude and a fixed full width at half maximum (FWHM) for the whole night. In the second type, the peak altitude and FWHM vary with the local time. SABER measurements are utilized to estimate the OH(6,2) band peak altitudes and FWHMs as a function of local time and considerable temporal variations are observed in both the parameters. The average temperature differences between the EFS and K‐Lidar obtained with both types of weighting functions are comparable with previously published results from different latitude‐longitude sectors. We found that the temperature comparison improves when the time‐varying weighting functions are considered. Comparison between EFS, K‐Lidar, and SABER temperatures reveal that on average, SABER temperatures are lower than the other two instruments and K‐Lidar temperatures compare better with SABER in comparison to EFS. Such a detailed study using the AO EFS data has not been carried out previously. 

Abstract Researchers have investigated whether machine learning (ML) may be able to resolve one of the most fundamental concerns in personnel selection, which is by helping reduce the subgroup differences (and resulting adverse impact) by race and gender in selection procedure scores. This article presents three such investigations. The findings show that the growing practice of making statistical adjustments to (nonlinear) ML algorithms to reduce subgroup differences must create predictive bias (differential prediction) as a mathematical certainty. This may reduce validity and inadvertently penalize high‐scoring racial minorities. Similarly, one approach that adjusts the ML input data only slightly reduces the subgroup differences but at the cost of slightly reduced model accuracy. Other emerging tactics involve weighting predictors to balance or find a compromise between the competing goals of reducing subgroup differences while maintaining validity, but they have been limited to two outcomes. The third investigation extends this to three outcomes (e.g., validity, subgroup differences, and cost) and presents an online tool. Collectively, the studies in this article illustrate that ML is unlikely to be able to resolve the issue of adverse impact, but it may assist in finding incremental improvements. 

High mental workload, in addition to changes in workload, can negatively affect operators, but it is not clear how sudden versus gradual workload transitions influence performance and visual attention allocation. This knowledge is important as sudden shifts in workload are common in multitasking domains. The objective of this study was to investigate, using performance and eye tracking metrics, how constant versus variable levels of workload affect operators in the context of a dual-task paradigm. An unmanned aerial vehicle command and control simulation varied task load between low, high, gradually transitioning from low to high, and suddenly transitioning from low to high. Performance on a primary and secondary task and several eye tracking measures were calculated. There was no significant difference between sudden and gradual workload transitions in terms of performance or attention allocation overall; however, both sudden and gradual workload transitions changed participants’ strategy in dealing with the primary and secondary task as compared to low/high workload. Also, eye tracking metrics that are not frequently used, such as transition rate and stationary entropy, provided more insight into performance differences. These metrics can potentially be used to better understand operators’ strategies and could form the basis of an adaptive display.